Proteins interact with each other and organize themselves into macromolecular machines (i.e., complexes) to carry out essential functions of cells.
Protein pairwise interactions and complexes
- We measured stable protein-protein interactions based co-fractionation mass spectrometry of 12 taxonomically diverse plant species (and tested in a 13th species, maize)
- Interactions can be queried using either UniProt Entry, Entry name, gene name, or TAIR AT locus ID.
- Higher-order multiprotein complexes were derived by clustering the pairwise interactions, and are presented with four different levels of clustering stringency, from most restrictive (smallest clusters) to most inclusive (largest clusters)
A note on orthology:
- As protein complexes were derived from multi-species data, they are indexed by eggNOG DB plant-level (virNOG) orthogroupID
- These orthogroups take the form ENOG411XXXX, and can be searched at the eggNOG website
- Due to gene expansions since the last common ancestor of plant, each orthogroup may contain more than one protein from a species
For further details see the publication describing this work:
- A pan-plant protein complex map reveals deep conservation and novel assemblies, by Claire D. McWhite, Ophelia Papoulas, Kevin Drew, Rachael M. Cox, Viviana June, Oliver Xiaoou Dong, Taejoon Kwon, Cuihong Wan, Mari L. Salmi, Stanley J. Roux, Jr., Karen S. Browning, Z. Jeffrey Chen, Pamela C. Ronald, Edward M. Marcotte. Cell 2020 DOI 10.1016/j.cell.2020.02.049
Contact  cmcwhite (at) princeton.edu
marcotte (at) icmb.utexas.edu